If your business depends upon the completeness, accuracy, security, and integrity of your data, then opt for a reliable client-server database engine such as Microsoft SQL Server or Oracle.
Do not be misled by false claims of client-server reliability when the database is built using a desktop "shared-file" database architecture, such as that offered by Microsoft Access. Microsoft Access is suitable for very small workgroups only. On a busy network it is highly susceptible to database corrpution.
We know Access well and use it often, but never for anything mission-critical, and usually as a quick query tool on relatively small datasets, especially when the data are stored in more than one database.